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ALZET滲透泵在實際應用上具有以下八大優點
發布時間： 2020-05-22 點擊次數： 1793次ALZET滲透泵是一種小型、可植入式的膠囊，可應用于小鼠、大鼠及其他實驗動物研究。該膠囊無需進行外部連接或頻繁處理，就能以恒定的速率持續給藥到四周的時間。ALZET滲透泵主要由藥物、半透膜材料、滲透壓活性物質和推動劑組成。ALZET滲透泵片是在片芯外包被一層聚合物構成的半透性衣膜，用激光在片劑衣膜層上開一個或多個適宜大小的釋藥小孔而制成。口服后，胃腸道內的水分通過半透膜進入片芯，因滲透壓活性物質使膜內溶液呈高滲，膜內外存在的滲透壓使水分繼續進入膜內，從而使藥物溶液或混懸的藥物從小孔泵出。常用的半透膜材料為醋酸纖維素。滲透壓活性物質起調節藥室內滲透壓的作用，其用量與零級釋藥時間長短有關，常用氯化鈉、乳糖、果糖、葡萄糖、甘露糖等。推動劑能吸水膨脹，將藥物層的藥物推出釋藥小孔，常用高分子量聚乙二醇等。除上述組成，ALZET滲透泵片中還可以加入助懸劑、黏合劑、潤滑劑、潤濕劑等。優點：1、可以向幾乎任何組織用藥；2、性價比很高的研究工具；3、提供了動物慢性定量給藥的簡單方法；4、解決了夜間及周末給藥的不便困擾；5、減少了對實驗動物的操作和應激影響；6、足夠小到可以應用到小鼠，及年幼大鼠；7、可以執行短效期的蛋白質及縮氨酸給藥；8、確保連續不斷得暴露在預定水平的測試藥物下。
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