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ALZET滲透泵在日常使用上擁有九大特點
發布時間： 2021-10-22 點擊次數： 1230次ALZET滲透泵型控釋片一般由片芯和包衣膜兩部分組成，按照結構特點，可將口服滲透泵制劑分為初級滲透泵和多室滲透泵兩類。初級滲透泵片芯中包含藥物和促滲透劑，包衣膜由高分子材料組成，包裹在片芯的表面。滲透泵片置于含水的環境中時，由于包衣膜內外存在滲透壓差，水分通過包衣膜后形成藥物的溶液或混懸液，在包衣膜內外滲透壓差的作用下，通過膜上的釋藥孔釋放。這種釋藥方式通常適用于在水中有一定溶解度的藥物。多室滲透泵制劑的片芯為雙層片，一層含有藥物及可溶解性輔料，另一層為遇水可膨脹的促滲透聚合物。這類滲透泵多適用于難溶性藥物滲透泵制劑的制備，釋藥過程由聚合物層膨脹產生推動力而將藥物混懸液推出釋藥孔。ALZET滲透泵的使用優點：1、體內外相關性較好，可避免普通口服制劑造成的血藥濃度波動較大的現象，提高用藥的安全性和有效性。2、ALZET滲透泵型控釋片以滲透壓為驅動力，以零級釋放動力學為釋藥特征，能夠在一定的時間范圍內以恒定的釋藥速率釋放藥物，釋藥速率一般不受釋放介質pH、攪拌速度以及胃腸蠕動、食物等因素影響，能夠在較長時間內維持恒速釋藥，減少用藥頻率。ALZET滲透泵產品特點：1、確保持續不間斷地均勻給藥；2、膠囊對半衰期短的藥物具有保護作用；3、減少了對實驗動物的操作和應激影響；4、可以執行短效期的蛋白質及縮氨酸給藥；5、體積小，可應用于小鼠或幼年大鼠等小動物實驗；6、確保將藥物準確輸送到靶部位，可以向幾乎任何組織用藥；7、確保連續不斷得暴露在預定水平的測試藥物下；8、使用方便，一次實驗僅需一次給藥，不再需要夜間或周末實驗；9、避免因重復給藥給動物造成的應激，從而減少非實驗因素對實驗結果的影響。
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